Role of Lymphadenectomy in Ovarian Cancer: Toward a Rational De-escalation Strategy
Seance of wednesday 06 may 2026 (Chirurgie Gynécologique)
DOI number : 10.26299/14ka-4024/emem.2026.19.03
Abstract
The role of lymphadenectomy in ovarian cancer management has been significantly redefined in recent years. In advanced stages, the LION trial demonstrated no improvement in overall or progression-free survival with systematic lymphadenectomy in patients without clinically suspicious lymph nodes, while increasing surgical morbidity. These findings support a de-escalation of nodal surgery in this setting.
In early-stage disease, lymphadenectomy remains important for staging purposes; however, its systematic use is increasingly debated due to its limited diagnostic yield and associated complications.
Sentinel lymph node mapping is emerging as a promising alternative, allowing targeted nodal assessment while minimizing morbidity. Although evidence is still limited, this approach may reshape future surgical strategies.
Overall, current trends favor a more individualized approach, aiming to reduce treatment-related morbidity without compromising oncological outcomes.
In early-stage disease, lymphadenectomy remains important for staging purposes; however, its systematic use is increasingly debated due to its limited diagnostic yield and associated complications.
Sentinel lymph node mapping is emerging as a promising alternative, allowing targeted nodal assessment while minimizing morbidity. Although evidence is still limited, this approach may reshape future surgical strategies.
Overall, current trends favor a more individualized approach, aiming to reduce treatment-related morbidity without compromising oncological outcomes.