Orthobiologic Regenerative Surgery Concepts for Vascular Wound Care Emerging Strategies in Healing Chronic and Complex Wounds
Seance of wednesday 24 september 2025 (Le traitement des plaies chroniques des membres inférieurs)
DOI number : 10.26299/xavv-2d49/emem.2025.39.05
Abstract
Orthobiologic regenerative surgery represents a rapidly evolving frontier in the field of vascular wound care. The primary goal is to harness the body’s inherent biological processes and augment them with advanced cellular and biologically derived therapies to promote wound healing, particularly in chronic or refractory wounds. As the prevalence of vascular wounds rises due to aging populations and increased incidence of comorbidities like, chronic venous and lymphatic insufficiency, diabetes, arterial occlusive diseases, there is an urgent demand for innovative, effective, and durable treatment options. This document explores the foundational concepts, key therapeutic approaches, and strategic clinical applications at the heart of orthobiologic regenerative wound care.
Key Orthobiologic and Regenerative Approaches
Orthobiologic therapies rely on substances that are naturally found within the body or closely related to natural components. In the context of vascular wound healing, these strategies focus on enhancing tissue regeneration, modulating inflammation, and promoting angiogenesis (formation of new blood vessels). Below are the principal modalities currently advancing the field: Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), Mesenchymal Stem Cells (MSCs), Stromal Vascular Fraction (SVF), Bioengineered Scaffolds and Advanced Dressings, Growth Factor Therapy
Despite the promise, several challenges remain:
• Standardizing preparation and application protocols across different clinics and providers
• Cost considerations and insurance coverage for advanced regenerative products
• Long-term safety and efficacy data, especially for allogeneic and engineered constructs
There is a clear need for well-designed, prospective clinical trials to establish evidence-based guidelines and optimize patient outcomes.
Conclusion
Orthobiologic regenerative surgery is transforming vascular wound care by providing biologically intelligent, patient-adapted solutions for complex wounds. The strategic use of autologous blood products, stem cells, stromal fractions, and advanced biomaterials is supported by a growing body of evidence. As research continues to refine these approaches, the future is bright for regenerative therapies to achieve faster, more complete, and more durable healing in patients with chronic and difficult wounds.
Founder and Pdt of the “Actual Regenerative Surgery International Academy”
https://www.arsia-academy.org
Key Orthobiologic and Regenerative Approaches
Orthobiologic therapies rely on substances that are naturally found within the body or closely related to natural components. In the context of vascular wound healing, these strategies focus on enhancing tissue regeneration, modulating inflammation, and promoting angiogenesis (formation of new blood vessels). Below are the principal modalities currently advancing the field: Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), Mesenchymal Stem Cells (MSCs), Stromal Vascular Fraction (SVF), Bioengineered Scaffolds and Advanced Dressings, Growth Factor Therapy
Despite the promise, several challenges remain:
• Standardizing preparation and application protocols across different clinics and providers
• Cost considerations and insurance coverage for advanced regenerative products
• Long-term safety and efficacy data, especially for allogeneic and engineered constructs
There is a clear need for well-designed, prospective clinical trials to establish evidence-based guidelines and optimize patient outcomes.
Conclusion
Orthobiologic regenerative surgery is transforming vascular wound care by providing biologically intelligent, patient-adapted solutions for complex wounds. The strategic use of autologous blood products, stem cells, stromal fractions, and advanced biomaterials is supported by a growing body of evidence. As research continues to refine these approaches, the future is bright for regenerative therapies to achieve faster, more complete, and more durable healing in patients with chronic and difficult wounds.
Founder and Pdt of the “Actual Regenerative Surgery International Academy”
https://www.arsia-academy.org