What about liver grafts constructed on the bench ?
Seance of wednesday 26 february 2025 (Transplantation hépatique : nouveaux patients, nouveaux donneurs, nouvelles techniques)
DOI number : 10.26299/s6gf-x543/2025.08.05
Abstract
There are three potential processes for bioconstruction of the liver :
The first is the chemical decellularization of the liver, followed by recellularization of the vascular skeleton, by perfusion of cells, possibly xenogeneic. In mice it results in a normal-looking, functional and transplantable liver but not in large animals. This process is coming back into fashion thanks to less aggressive decellularization techniques.
The second is 3-D bioprinting. Currently the only tissue constructed by bioprinting is skin. Bioprinting of complex organs still seems very far away.
The third consists of creating multicellular organoids from stem cells, having the function and not the shape of the liver. After intraperitoneal implantation, these organoids extend the life of mice with acute liver failure. These organoids could make it possible to overcome an acute crisis in humans suffering from fulminant hepatitis or ACLF. There are no clinical trials underway yet.
The first is the chemical decellularization of the liver, followed by recellularization of the vascular skeleton, by perfusion of cells, possibly xenogeneic. In mice it results in a normal-looking, functional and transplantable liver but not in large animals. This process is coming back into fashion thanks to less aggressive decellularization techniques.
The second is 3-D bioprinting. Currently the only tissue constructed by bioprinting is skin. Bioprinting of complex organs still seems very far away.
The third consists of creating multicellular organoids from stem cells, having the function and not the shape of the liver. After intraperitoneal implantation, these organoids extend the life of mice with acute liver failure. These organoids could make it possible to overcome an acute crisis in humans suffering from fulminant hepatitis or ACLF. There are no clinical trials underway yet.