L'imagerie de la rétine chez l'humain : la dynamique cellulaire à l'œuvre dans l'inflammation.

Inflammation plays a crucial role in neurodegenerative pathologies of the central nervous system, including Alzheimer's disease and multiple sclerosis (MS), among others. However, gaining access to the pathological and inflammatory cellular processes that lead to neurodegeneration poses a significant challenge. The eye, being the sole transparent optical window of our body, offers a distinctive and non-invasive avenue to explore neuronal networks.

We are designing new high-precision retinal imaging systems at the Clinical Investigation Center of the Hôpital des Quinze-Vingts, allowing us to observe for the first time the immune responses at different stages of neurodegenerative diseases. These observations offer cellular resolution up to the detection of intracellular structures such as the nucleus. This progress is taking place in an exceptional framework, where clinicians and engineers collaborate closely within the Hôpital des Quinze-Vingts, in partnership with the Institut de la Vision and the Institut du Cerveau.