Adipose derived products used in the orthopedic field

The discovery of the presence of mesenchymal stem cells in adipose tissue in the early 2000s made adipose tissue a valuable source in the development of regenerative medicine procedures. Indeed, the accessibility and abundance of adipose tissue in the body, associated with the presence of mesenchymal stem cells within the microvessels of adipose tissue, capable of differentiation towards the chondrogenic lineage, have highlighted the potential of adipose derived products for cartilage regeneration. Among the latter, microfat is simply obtained by harvesting fat using a multi-perforated cannula selecting lobules of approximately 600 µm in diameter. This presentation will address the current developments of the Assistance Publique des Hôpitaux de Marseille using autologous microfat in the management of knee and wrist osteoarthritis as well as a short review of the literature of other products derived from adipose tissue used in this field (stromal vascular fraction, microfragmented fat, emulsified fat, cultured mesenchymal stem cells).