Biomecanobiology of Complex Aortic Aneurysms and Dissections: New Therapeutic Approach
Seance of wednesday 09 september 2020 (Communications libres)
DOI number : 10.26299/gey0-hb91/emem.2018.3.018
Abstract
Complex aortic dissections and aneurysms, are difficult cases to treat, where the benefit/risk of treatment is difficult to demonstrate.
Mecanobiology, a new discipline, has made it possible to study, and demonstrate that the majority of biological processes at different scales are linked to mechanical stresses and deformations.
Biomechanics have been known since Aristotle, but since the 2000s, the rise in power of numerical simulation of the biomechanical properties of the wall, and a better understanding of its biological function, have made it possible to predict the behavior of arterial tissues.
The coupling of these two properties: Biomecanobiology makes it possible to understand how vascular cells respond to different forces, which can explain the types of stresses governing remodeling, the rupture of the arterial wall or the blood flow behavior.
The concept of the three-dimensional multilayer flow modulator device -MFM®- (Cardiatis Isnes Belgique) integrates different aspects of biomecanobiology, in order to take in consideration, the behavior of blood flow and the biology of the wall.
MFM® biomecanobiology is based on four key fundamental principles:
- Transformation of turbulent flow into laminar flow
- Lamination leads to an organized stable thrombus
- Maintaining organ perfusion
- Endothelialization
The results of this MFM® concept will be illustrated by examples of treated aneurysms and dissections.
Mecanobiology, a new discipline, has made it possible to study, and demonstrate that the majority of biological processes at different scales are linked to mechanical stresses and deformations.
Biomechanics have been known since Aristotle, but since the 2000s, the rise in power of numerical simulation of the biomechanical properties of the wall, and a better understanding of its biological function, have made it possible to predict the behavior of arterial tissues.
The coupling of these two properties: Biomecanobiology makes it possible to understand how vascular cells respond to different forces, which can explain the types of stresses governing remodeling, the rupture of the arterial wall or the blood flow behavior.
The concept of the three-dimensional multilayer flow modulator device -MFM®- (Cardiatis Isnes Belgique) integrates different aspects of biomecanobiology, in order to take in consideration, the behavior of blood flow and the biology of the wall.
MFM® biomecanobiology is based on four key fundamental principles:
- Transformation of turbulent flow into laminar flow
- Lamination leads to an organized stable thrombus
- Maintaining organ perfusion
- Endothelialization
The results of this MFM® concept will be illustrated by examples of treated aneurysms and dissections.