Role of Surgery for the Treatment of Ovarian Cancer First Relapse

Two third of patients treated for an Advanced ovarian cancer experience a relapse during the first two years after the end of initial treatment. This relapse appears as a peritoneal carcinomatosis. Severel published series and a Meta-analysis have shown survival encouraging results in terms of survival. The German Desktop III trial is a prospective randomized trial aimed to demonstrate survival improvement.Hyperthermic Intraperitoneal chemotherapy (HIPEC) is an innovative combined treatment with complete surgery and heated intraperitoneal chemotherapy. Several series have demonstrate feasibility, an acceptable rate of complication and encouraging survival results when HIPEC is performed for selected patients, by an experienced team. Only Small clinical series have a control group. Two prospective randomized trials are ongoing in Europe to demonstrate survival improvement: HORSE trial in Italy and CHIPOR trial in France.