Animal study of a new thermoablation procedure

Seance of wednesday 26 may 2004 (pas de sujet Principal)

Abstract

Aim of the study : The new focalised thermoablation with implant -able microtube technique presented here to resect liver metastases isan efficient method if performed under the imaging modalities currentlyavailable. This new technique of thermoablation was experimentallyvalidated in vivo, as well as its efficacy on tumors graftedon mice on one hand and by destroying large volumes of liver onpigs on the other.Material and Method : The thermoablation with vaporized water at400oC injected through the microtube has been experimented on 30mice grafted with a human colon tumor and on the healthy liver of12 pigs.Results : The destruction of the tumors grafted on mice was alwaysachieved as well as a significant volume of liver parenchyma on thepigs. The clinical and biological follow-up has shown that the treat -ment was well tolerated. The images allowed an excellent control ofthe evolution of the necrosis. The anatomo-pathology has provedthat necrosis was total in most of the cases.Conclusion : This study on mice and pigs has demonstrated thefeasibility of the technique. The efficacy is well demonstrated onthe photographs and by the anatomo-pathology that shows a completenecrosis in most of the cases.